The seven vehicle crash happened between the Salunga exit and the exit for Route 722 - Landisville, near Spooky Nook Road, on Monday, Apr, 25 at 10:50 a.m., according to PennDOT.
The seven vehicles involved were two tractor-trailers, a transit van, three passenger vehicles, and one construction vehicle, according to responding police.
The transit van came to a stop in the right eastbound lane, and a tractor-trailer slammed into cause what East Hempfield Township police are calling a "chain reaction crash."
"Two of the drivers were taken to a hospital for what appeared to be minor injuries," police say.
All lanes of traffic were closed in the area for approximately two hours.
The crash remains under investigation.
Click here to follow Daily Voice Cornwall-Mount Gretna and receive free news updates.